(2018) Mechanisms of diazinon effects on impaired spermatogenesis and male infertility. Toxicology and Industrial Health. pp. 653-664. ISSN 0748-2337
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Abstract
Diazinon (DZN) is an organophosphate insecticide that has cytotoxic and pathological effects on the reproductive system. It causes a wide variety of pathological effects on the reproductive system such as testicular atrophy, disturbance in sex hormones, impaired spermatogenesis, low quality of sperm, and fertility problems. However, molecular and cellular mechanisms of its adverse effects are not well understood. General events such as testicular damage, inflammation, mitochondrial deficiency, DNA fragmentation, disintegration of sperm plasma membrane, apoptosis, and cell death are observed in DZN-exposed animals. Oxidative stress (OS) induced by reactive oxygen species may be a main mechanism, which can be associated with sperm DNA fragmentation, reduced integrity of sperm cell membrane, apoptosis, depletion of antioxidants, and subsequently poor sperm quality and male infertility. Therefore, identification of these pathways may provide valuable information regarding the mechanisms of DZN action on the male reproductive system. In this review, we aim to discuss the proposed cellular and molecular mechanisms of DZN action on male reproductive system, the importance of OS and mechanisms by which DZN induces OS and depletion of other antioxidants.
Item Type: | Article |
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Keywords: | Diazinon oxidative stress reproductive system sperm male infertility sperm chromatin-structure induced oxidative stress dna-damage pesticide exposure in-vitro organophosphate pesticide induced hepatotoxicity lepomis-macrochirus lipid-peroxidation induced apoptosis Public, Environmental & Occupational Health Toxicology |
Divisions: | |
Page Range: | pp. 653-664 |
Journal or Publication Title: | Toxicology and Industrial Health |
Journal Index: | ISI |
Volume: | 34 |
Number: | 9 |
Identification Number: | https://doi.org/10.1177/0748233718778665 |
ISSN: | 0748-2337 |
Depositing User: | مهندس مهدی شریفی |
URI: | http://eprints.bmsu.ac.ir/id/eprint/3652 |
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